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Neuron-Glia Interactions in Health and Disease
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CRUMBS > Publications

Consortium publications

 

The consortium was established in the year 2000.

Publications of the Crumbs consortium before EC funding started September 1,2002.

  1. den Hollander, A.I., ten Brink, J.B., de Kok, Y.J.M., van Soest, S., van den Born, L.I., van Driel, M.A., van de Pol, T.J.R., Payne, A.M., Bhattacharya, S.S., Kellner, U., Hoyng, C.B., Westerveld, A., Brunner, H.G., Bleeker-Wagemakers, E.M., Deutman, A.F., Heckenlively, J.R., Cremers, F.P.M.,Bergen, A.A.B. (1999) Mutations in a human homologue of Drosophila crumbs cause retinitis pigmentosa (RP12) Nature Genet. 23:217-221.
  2. den Hollander, A.I., Heckenlively, J.R., van den Born, L.I. de Kok, Y.J.M., van der Velde-Visser, S.D., Kellner, U., Jurklies,B., van Schooneveld, M.J., Blankenagel, A., Rohrschneider, K., Wissinger, B., Cruysberg, J.R.M., Deutman, A.F., Brunner, H.G., Apfelstedt-Sylla, E., Hoyng, C.B., Cremers , F.P.M. (2001) Leber congenital amaurosis and retinitis pigmentosa with Coats-like exudative vasculopathy are associated with mutations in the crumbs homologue 1 ( CRB1 ) gene. Am. J. Hum. Genet . 69:198-203
  3. den Hollander, A.I., Johnson, K., de Kok, Y. J. M., Klebes, A., Brunner, H.G., Knust , E., Cremers , F.P.M. (2001). CRB1 has a cytoplasmic domain that is functionally conserved between human and Drosophila . Hum. Mol. Gen. 10:2767-2773.
  4. Cremers , F.P.M., van den Hurk J.A.J.M., den Hollander, A.I. (2002). Molecular genetics of Leber congenital amaurosis. Hum. Mol. Genet. 15:1169-1176.
  5. den Hollander, A.I., Ghiani, M., de Kok, Y.J.M., Wijnholds, J., Ballabio, A., Cremers, F.P.M., Broccoli, V. (2002) Isolation of Crb1, a mouse homologue of Drosophila crumbs, and analysis of its expression pattern in eye and brain. Mech. Dev. 110:203-207.
  6. Johnson, K., Grawe, F., Grzeschik, N. and Knust , E. (2002). Drosophila Crumbs is required to inhibit light-induced photoreceptor degeneration. Curr. Biol. 12:1675-1680.
  7. Knust , E. and Bossinger, O. (2002). Epithelial cell polarity: Composition and formation of intercellular junctions in different organisms. Science 298:1955-1959.
  8. Knust , E. Regulation of epithelial cell shape and polarity by cell-cell adhesion (2002). Molecular Membrane Biology 19:113-120.
  9. Lemmers, C., Médina, E., Delgrossi, M-H., Michel, D., Arsanto, J.P., Le Bivic , A. (2002). HinaDl/PATJ, a homolog of Discs lost, interacts with crumbs and localizes to tight junctions in human epithelial cells. J. Biol. Chem. 277:25408-25415.
  10. Médina, E., Lemmers, C., Lane-Guermonprez, L., Le Bivic , A. (2002). Role of the Crumbs complex in the regulation of junction formation in Drosophila and mammalian epithelial cells. Biol. Cell. 94:305-314.
  11. Médina, E., Williams, J., Klipfell, E., Zarnescu, D., Thomas, G., Le Bivic , A. (2002). Crumbs interacts with Moesin and β-heavy-Spectrin in the apical membrane skeleton of Drosophila . J. Cell Biol. 158:941-951.
  12. Lemmers, C., Médina, E., Lane-Guermonprez, L., Arsanto, J.P., Le Bivic , A. (2004). Rôle des protéines Crumbs dans le contrôle la morphogenèse des cellules épithéliales et des photorécepteurs. M/S. 20 : 663-667.
  13. Bachmann, A., Timmer, M., Sierralta, J., Pietrini, G., Gundelfinger, E.D., Knust, E., Thomas, U. (2004). Cell type-specific recruitment of Drosophila Lin-7 to distinct MAGUK-based protein complexes defines novel roles for Sdt and Dlg-S97. J. Cell Sci. 117:1899-909.
  14. Cremers, F.P.M., Maugeri, A., den Hollander, A.I., Hoyng, C.B. (2004). The expanding roles of ABCA4 and CRB1 in inherited blindness. Novartis Found Symposium 255:68-79; discussion 79-84, 177-178.
  15. den Hollander, A.I., Davis, J., van der Velde-Visser, S.D., Zonneveld, M.N., Pierrottet, C.O., Koenekoop, R.K. Kellner, U., van den Born, L.I., Heckenlively, J.R., Hoyng, C.B., Handford, P.A., Roepman, R., Cremers, F.P.M. (2004). CRB1 mutation spectrum in inherited retinal dystrophies. Hum. Mutat. 24:355-369.
  16. Lemmers, C. Medina, E., Lane-Guermonprez, L., Arsanto, J.-P., Le Bivic, A. (2004). The Crumbs protein and the control of epithelial cell and photoreceptor morphogenesis. Med Sci (Paris) . 20:663-667.
  17. Lemmers, C., Michel, D., Médina, E., Delgrossi M.-H., Arsanto, J.-P., Le Bivic , A. (2004). CRB3 regulates the morphogenesis of the apical membrane and tight junctions in mammalian epithelial cells. Mol. Biol. Cell. 15:1324-1333.
  18. Meuleman, J., van de Pavert, S.A., Wijnholds , J. (2004) Crumbs homologue 1 in polarity and blindness. Biochem. Soc. Trans. 32:828-830.
  19. van de Pavert, S., Kantardzhieva, A., Malysheva, A., Meuleman, J., Versteeg, I., Levelt, C., Klooster, J., Geiger, S., Seeliger, M., Rashbass , P., Le Bivic , A., Wijnholds , J. (2004). Crumbs homologue 1 is required for maintenance of photoreceptor cell polarization and adherence during light exposure. J. Cell Sci. 117:4169-4177.
  20. Rodriguez-Boulan, E., Musch, A., Le Bivic, A. (2004). Epithelial trafficking: new routes to familiar places. Curr. Opin.Cell Biol. 16:436-442.
  21. Grzeschik, N. and Knust , E. (2005) IrreC/rst-mediated cell sorting during Drosophila pupal eye development depends on proper localisation of DE-cadherin. Development 132:2035-2045.
  22. van den Hurk, J.A.J.M., Rashbass , P., Roepman, R., Davis, J., Voesenek, K.E.J., Arends, M.L., Zonneveld, M.N., van Roekel, M.H.G., Cameron, K., Rohrschneider, K., Heckenlively, J.R., Koenekoop, R.K., Hoyng, C.B., Cremers , F.P.M., den Hollander, A.I. (2005) Characterization of the Crumbs homolog 2 ( CRB2 ) gene and analysis of its role in retinitis pigmentosa and Leber congenital amaurosis. Mol. Vis. , 11:263-273.
  23. van den Hurk JA, Rashbass P, Roepman R, Davis J, Voesenek KE, Arends ML, Zonneveld MN, van Roekel MH, Cameron K, Rohrschneider K, Heckenlively JR, Koenekoop RK, Hoyng CB, Cremers FP, den Hollander AI. (2005). Characterization of the Crumbs homolog 2 (CRB2) gene and analysis of its role in retinitis pigmentosa and Leber congenital amaurosis. Mol Vis. 11:263-73.
  24. Kantardzhieva, A., Gosens, I., Alexeeva, S., Punte, I.M., Versteeg, I., Krieger, E., Neefjes-Mol, C.A., den Hollander, A.I., Letteboer, S.J.F., Klooster, J., Cremers, F.P.M., Roepman, R. and Wijnholds, J. (2005) MPP5 recruits MPP4 to the CRB1 complex in photoreceptors. Invest. Ophthalmol. Vis. Sci. 46:2192-201.
  25. Michel, D., Arsanto, J. P., Massey-Harroche, D., Beclin, C., Wijnholds, J., and Le Bivic, A. (2005). PATJ connects and stabilizes apical and lateral components of tight junctions in human intestinal cells. J.Cell Sci 118:4049-57.
  26. Seeliger,M.W., Beck,S., Pereyra-Muñoz,N., Dangel,S., Tsai,J.-Y., Luhmann,U., van de Pavert,S., Wijnholds,J., Samardzija,M., Wenzel,A., Zrenner,E., Fahl,E., Tanimoto,N., Acar,N., and Tonagel,F. (2005). In vivo confocal imaging of the retina in animal models using scanning laser ophthalmoscopy. Vision Res. 45:3512-9.

  

Publications of the Crumbs consortium since 2006.

  1. Aartsen,W.M., Kantardzhieva,A., Klooster, J., van Rossum,A.G. van de Pavert,S.A., Versteeg,I., Nunes Cardozo,B., Tonagel,F., Beck,S.C., Tanimoto,N., Seeliger,M.W., and Wijnholds,J. (2006). Mpp4 recruits Psd95 and Veli3 towards the photoreceptor synapse. Hum. Mol. Genet., 15:1291-302.
  2. Delacour D., Cramm-Behrens C.I., Drobecq H., Le Bivic A., Naim H.Y. & Jacob R. (2006). Requirement for Galectin-3 in apical sorting. Curr. Biol. 16 :408-414.
  3. Gavarini,S., Becamel,C., Altier,C., Lory,P., Poncet,J., Wijnholds,J., Bockaert,J., and Marin,P. (2006) Opposite effects of PSD-95 and MPP3 PDZ proteins on serotonin 5-HT2C receptor desensitization and membrane stability. Mol. Biol. Cell, 17: 4619-4631.
  4. Kantardzhieva,A., Alexeeva,S., Versteeg,I., and Wijnholds,J. (2006) MPP3 is recruited to the MPP5 protein scaffold at the retinal outer limiting membrane. FEBS J. 273:1152-1165.
  5. Kempkens O., Médina E., Fernandez-Ballester G., Özüyaman S., Le Bivic A., Serrano L. and Knust E. Computer modelling in combination with in vitro studies reveals similar binding affinities of Drosophila Crumbs for the PDZ domains of Stardust and DmPar-6. 2006. Eur. J. Cell Biol.
  6. Richard,M., Roepman,R., Aartsen,W.M., van Rossum,A.G., den Hollander,A.I., Knust,E., Wijnholds,J., and Cremers,F.P. (2006). Towards understanding CRUMBS function in retinal dystrophies. Hum. Mol. Genet., 15: R235-R243.
  7. Richard, M., Grawe, F., and Knust, E. (2006). DPATJ plays a role in retinal morphogenesis and protects against light-dependent degeneration of photoreceptor cells in the Drosophila eye. Dev. Dyn. 235, 895-907.
  8. van Rossum,A.G., Aartsen,W.M., Meuleman,J., Klooster,J., Malysheva,A., Versteeg,I., Arsanto,J.-P., Le Bivic,A., and Wijnholds,J. (2006). Pals1/Mpp5 is required for correct localization of Crb1 at the sub-apical region in polarized Müller glia cells. Hum. Mol. Genet., 15 :2659-72.
  9. Yzer, S., Fishman, G. A., Racine, J., Al-Zuhaibi, S., Chakor, H., Dorfman, A., Szlyk, J., Lachapelle, P., van den Born, L. I., Allikmets, R., Lopez, I., Cremers, F. P. M. & Koenekoop, R. K. CRB1 heterozygotes with regional retinal dysfunction: Implications for genetic testing of Leber congenital amaurosis. (2006) Invest. Ophthalmol. Vis. Sci. 47, 3736-3744.
  10. Yzer, S., Leroy, B. P., De Baere, E., de Ravel, T. J., Zonneveld, M. N., Voesenek, K., Kellner, U., Martinez Ciriano, J. P., de Faber, J.-T. H. N., Rohrschneider, K., Roepman, R., den Hollander, A. I., Cruysberg, J. R., Meire, F., Casteels, I., van Moll-Ramirez, N. G., Allikmets, R., van den Born, L. I. & Cremers, F. P. M. Microarray-based mutation detection and phenotypic characterization of patients with Leber congenital amaurosis. (2006) Invest. Ophthalmol. Vis. Sci. 47, 1167-1176.
  11. Berger, S., Bulgakova, N. A., Grawe, F., Johnson, K. and Knust, E. (2007). Unravelling the genetic complexity of Drosophila stardust during photoreceptor morphogenesis and prevention of light-induced degeneration. Genetics, 176, 2189-2200.
  12. Delacour D., Greb C., Koch A., Salomonsson E., Leffler H., Le Bivic A. and Jacob R. 2007. Apical Sorting by Galectin-3 Dependent Glycoprotein Clustering. Traffic. 8 :379-88.
  13. Helfrich I., Schmitz A., Zigrino P., Michels C., Haase I., Le Bivic A., Leitges M., and  Niessen C. 2007. Role of aPKC isoforms and their binding partners Par3 and Par6 in epidermal barrier formation. J. Invest. Dermatology. 127 :782-91.
  14. Gosens, I., Wijk, E. van, Kersten, F. F. J., Krieger, E., van der Zwaag, B., Marker, T., Letteboer, S. J. F., Dusseljee, S., Peters, T., Spierenburg, H. A., Punte, I. M., Wolfrum, U., Cremers, F. P. M., Kremer, H. & Roepman, R. MPP1 links the Usher protein network and the Crumbs protein complex in the retina. (2007). Hum. Mol. Genet., 16, 1993-2003.
  15. Knust, E. (2007) Photoreceptor morphogenesis and retinal degeneration: lessons from Drosophila. Curr. Opinion Neurobiol. 17, 541-547
  16. Knust, E., Huttner, W.B. (2007). Cell polarity from cell division. Dev. Cell 12, 664-666. (Commentary).
  17. Massey-Harroche D., Delgrossi M.H., Lane-Guermonprez L., Arsanto J.P., Borg J.P., Billaud M. and Le Bivic, A. 2007. Evidence for a molecular link between the Tuberous Sclerosis complex and the Crumbs complex. A. Hum. Mol. Genet. 16 :529-36.
  18. Peachey NS, Ridder WH 3rd, Seeliger MW. Electrophysiologic assessment of the mouse visual system. Doc Ophthalmol. 2007 Nov;115(3):125.
  19. Van de Pavert,S.A., Sanz Sanz,A., Aartsen,W.M., Vos,R.M., Versteeg,I., Beck,S.C., Klooster,J., Seeliger,M.W., and Wijnholds,J. (2007) Crb1 is a determinant of retinal apical Mueller glia cell features. Glia 55(14):1486-97.
  20. Van de Pavert,S.A., Meuleman,J., Malysheva,A., Aartsen, W.M., Versteeg,I., Tonagel, T., Kamphuis, W., McCabe, C.J., Seeliger,M.W., and Wijnholds,J. (2007). A single amino acid substitution (Cys249Trp) in the sixth epidermal growth factor (EGF) domain of Crb1 causes retinal degeneration and deregulates expression of Pituitary tumor transforming gene 1 (Pttg1). J. Neurosci., 27:564-573.
  21. Assémat, E., Bazellières, E., Pallesi, E., Le Bivic, A. & Massey-Harroche, D. 2008. Polarity complex proteins. BBA biomembranes. 1778 :614-30.
  22. Bachmann, A., Grawe, F. and Knust, E. (2008). Drosophila Lin-7 is a component of the Crumbs complex in epithelia and photoreceptor cells and prevents light-induced retinal degeneration. Eur. J. Cell Biol. 87, 123-136.
  23. Bulgakova, N. A., Kempkens, Ö. and Knust, E. (2008). Multiple domains of Drosophila Stardust differentially mediate localisation of the Crumbs/Stardust complex during photoreceptor development (2008). J. Cell Sci. 121, 2018-1026.
  24. Fahl E, Gassmann M, Grimm C, Seeliger MW. Oxygen supply and retinal function: insights from a transgenic animal model. Adv Exp Med Biol. 2008;613:171-7.
  25. Langrová H, Zrenner E, Kurtenbach A, Seeliger MW. Age-related changes in retinal functional topography. Invest Ophthalmol Vis Sci. 2008 Nov;49(11):5024-32. den Hollander, A. I., Roepman, R., Koenekoop, R. K. & Cremers, F. P. M. Leber congenital amaurosis: genes, proteins and disease mechanisms. (2008). Prog. Retin. Eye Res. 27, 391-419.
  26. Gosens, I., den Hollander, A. I., Cremers, F. P. M. & Roepman, R. Composition and function of the Crumbs protein complex in the mammalian retina. (2008). Exp. Eye Res. 86, 713-726.
  27. Aartsen, W.M., Arsanto, J.-P., Chauvin, J.-P., Vos, R.M., Versteeg, I., Nunes Cardozo, B., Le Bivic, A., Wijnholds, J. (2009) PSD95β regulates plasma membrane Ca(2+) pump localization at the photoreceptor synapse. Mol. Cell. Neurosci., 41 :156-65.
  28. Bardin, N., Blot-Chabaud, M., Despoix, N., Kebir, A., Harhouri, K., Arsanto, J.P., Spinosa, L., Perrin, P., Robert, S., Vely, F., Sabatier, F., Le Bivic, A., Kaplanski, G., Sampol, J., Dignat-George, F. 2009. CD146 and its Soluble Form Regulate Monocyte Transendothelial Migration. Arterioscler Thromb Vasc Biol. 29 :746-53.
  29. Bazellieres, E., Assemat, E., Arsanto, J.P., Le Bivic, A. & Massey-Harroche, D. 2009. Crumbs proteins and epithelial morphogenesis. Frontiers in Biosciences. 14:2149-69.
  30. Stöhr,H., Heisig,J.B., Milenkovic,V., Strauss,O., Benz1,P.M., Aartsen,W.M., Wijnholds,J., Weber,B.H.F., Schulz, H.L. (2009) TMEM16B, a novel protein with calcium-dependent chloride channel activity, associates with a presynaptic protein complex in photoreceptor terminals. J. Neurosci., 29 :6809-18.
  31. Lavelle C., Berry H., Beslon G., Ginelli, F., Giavitto J-L., Kapoula Z., Le Bivic A., Peyrieras N., Radulescu, O., Six, A., Thomas-Vaslin V. & Bourgines, P. From Molecules to organisms: towards multiscale integrated models of biological systems. Theoretical Biology Insights.
  32. Delous, M., Hellman, N.E., Gaude, H.M., Silberman, F., Le Bivic, A., Salomon, R., Antignac, C. and Saunier, S. 2009. Nephrocystin-1 and Nephrocystin-4 are required for epithelial morphogenesis and associate with Pals1/Patj and PAR6. Hum. Mol. Genet. 18:4711-28.
  33. Bulgakova, N. and Knust, E. (2009). The Crumbs complex. From epithelial cell polarity to retinal degeneration. J. Cell Sci. 122, 2587-2596
  34. Richard, M., Muschalik, N., Grawe, F., Özüyaman, S. and Knust, E. (2009). A role for the extracellular domain of Crumbs in morphogenesis of Drosophila photoreceptor cells. Eur. J. Cell Biol. 88, 765-777.
  35. Kock, I., Bulgakova, N. A., Knust, E., Sinning, I. and Panneels, V. (2009). Targeting of Drosophila rhodopsin requires helix 8 but not the distal C-terminus. PLoS One 4, e6101
  36. Fischer MD, Huber G, Beck SC, Tanimoto N, Muehlfriedel R, Fahl E, Grimm C, Wenzel A, Remé CE, van de Pavert SA, Wijnholds J, Pacal M, Bremner R, Seeliger MW. (2009). Noninvasive, in vivo assessment of mouse rétinal structure using optical coherence tomography. PLoS One. 4:e7507.
  37. Cremers, F. P. M. & Collin, R. W. J. Promises and challenges of genetic therapy for blindness. (2009) Lancet 374, 1569-1570.
  38. Huber G, Beck SC, Grimm C, Sahaboglu-Tekgoz A, Paquet-Durand F, Wenzel A, Humphries P, Redmond TM, Seeliger MW, Fischer MD. (2009). Spectral domain optical coherence tomography in mouse models of retinal degeneration. Invest Ophthalmol Vis Sci. 50(12):5888-95
  39. Aartsen,W.M., van Cleef,K.W.R., Pellissier,L., Hoek,R.M., Vos,R.M., Blits,B., Ehlert,E.M.E., Balaggan,K.S., Ali,R.R., Verhaagen,J. and Wijnholds,J. (2010) GFAP-driven GFP expression in activated mouse Müller glial cells aligning retinal blood vessels following intravitreal injection of AAV2/6 vectors. PLoS One 5(8): e12387.
  40. Kim,S., Lehtinen,M.K., Sessa,A., Zappaterra,M.W., Cho,S.-H., Gonzalez,D., Boggan,B., Austin,C.A., Wijnholds,J., Gambello,M.J., Malicki,J., LaMantia,A..S., Broccoli,V., and Walsh,C.A. (2010) The apical complex couples cell fate and cell survival to cerebral cortical development. Neuron 66, 69-84.
  41. Jaissle,G.B., May,C.A., van de Pavert,S.A., Wenzel,A., Claes-May,E., Giessle,A., Szurman,P., Wolfrum,U., Wijnholds,J., Fisher,M.D., Humphries,P., Seeliger,M.W. (2010) Bone spicule pigment formation in retinitis pigmentosa: insights from a mouse model. Graefes Arch Clin Exp Ophthalmol. 248(8):1063-70.
  42. den Hollander, A. I., Black, A., Bennett, J. & Cremers F. P. M. Lighting a candle in the dark: advances in genetics and gene therapy of recessive retinal dystrophies. (2010) J. Clin. Invest. 120, 3042-3053.
  43. Michalakis S, Mühlfriedel R, Tanimoto N, Krishnamoorthy V, Koch S, Fischer MD, Becirovic E, Bai L, Huber G, Beck SC, Fahl E, Büning H, Paquet-Durand F, Zong X, Gollisch T, Biel M and Seeliger MW. (2010). Restoration of Cone Vision in the CNGA3−/− Mouse Model of Congenital Complete Lack of Cone Photoreceptor Function. Molecular Therapy , in press.
  44. Schaeferhoff K, Michalakis S, Tanimoto N, Fischer MD, Becirovic E, Beck SC, Huber G, Rieger N, Riess O, Wissinger B, Biel M, Seeliger MW, Bonin M. (2010).  Induction of STAT3-related genes in fast degenerating cone photoreceptors of cpfl1 mice. Cell. Mol. Life Sci. 67:3173–3186
  45. Fischer MD, Huber G, Feng Y, Tanimoto N, Mühlfriedel R, Beck SC, Tröger E, Kernstock C, Preising MN, Lorenz B, Hammes HP, Seeliger MW. (2010). In vivo assessment of retinal vascular wall dimensions. Invest Ophthalmol Vis Sci. 51(10):5254-9
  46. Beck SC, Schaeferhoff K, Michalakis S, Fischer MD, Huber G, Rieger N, Riess O, Wissinger B, Biel M, Bonin M, Seeliger MW, Tanimoto N. (2010). In vivo analysis of cone survival in mice. Invest Ophthalmol Vis Sci. 51(1):493-7.
  47. Bachmann, A., Kobler, O., Kittel, R., Wichmann, C., Sierralta, J., Sigrist, S., Gundelfinger, E., Knust, E. and Thomas. U. (2010). A perisynaptic Ménage-à-trois between Dlg, DLin-7 and Metro controls proper organization of Drosophila synaptic junctions. J. Neurosci. 30, 5811-5824     
  48. Bulgakova, N. A., Rentsch, M. and Knust, E. Antagonistic functions of two Stardust isoforms in Drosophila photoreceptor cells. Mol. Biol. Cell (in press)