Seventh Framework Programme
HEALTH-2007-2.2.1-6
Neuron-Glia Interactions in Health and Disease
Collaborative Project
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CRUMBS > Current Knowledge

CRB1, current knowledge

We will illustrate the different diseases which are caused by mutations in the CRB1 gene, outline its mutation spectrum, and describe novel techniques that enable cost-effective mutation analysis. Furthermore, we will schematically depict its function in the retina and describe some typical features of the defective retina in mouse and man. In addition, we will briefly outline consortium studies of fruitfly Crumbs as well as mammalian homologues of CRB1: CRB2 and CRB3.